CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update Synthesis and Immunologic Characterisation of Mycobacterium
Hamasur, Beston; Kallenius, Gunilla; Svenson, Stefan B.
July 23, 1999
Vaccine Online (07/16/99) Vol. 17, No. 22, P. 2853
Swedish researchers synthesized and immunologically
characterized immunogenic lipoarabinomannan (LAM)-specific
oligosaccharide protein conjugates. The researchers derived
the oligosaccharides from LAM purified from Mycobacterium
tuberculosis H37 Rv and covalently conjugated to tetanus
toxoid and cross-reactive mutant diphtheria toxoid. "Both
types of LAM oligosaccharide protein conjugates proved to be
highly immunogenic, inducing a boosterable T helper cell
dependent IgG response," the authors report. Such conjugates
are currently being assessed as components for an experimental
subcellular TB vaccine.