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CDC HIV/AIDS/Viral Hepatitis/STD/TB Prevention News Update
US Researchers Identify HIV-Friendly Proteins

October 21, 2003
Agence France Presse (10.17.03) - Tuesday, October 21, 2003

US researchers have identified a series of proteins that enable HIV to bypass the human body's natural antiviral defenses, a discovery they say could lead to new treatments for HIV/AIDS. "We've discovered a new link in the chain that allows the HIV to overcome the cellular resistant factor and to infect human cells," Dr. Xiao-Fang Yu, associate professor at Johns Hopkins Bloomberg School of Public Health, wrote in "Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex," published in the on-line edition of Science magazine (10.16.03; 10.1126/science.1089591). The report noted that HIV contains a viral infection factor essential to escaping the body's natural antiviral agent. The virus acts in conjunction with a group of proteins to modify and disable this protective agent, according to the researchers.