Reuters (07.06.07) - Wednesday, July 11, 2007
Persons with HIV infection are at higher risk for developing
lung cancer, independent of cigarette smoking, a new study
Dr. Gregory D. Kirk of the Bloomberg School of Public Health
at Johns Hopkins University in Baltimore and colleagues
examined lung cancer deaths in a cohort of injection drug
users followed since 1998 as part of an AIDS study. Among the
2,086 participants, 27 lung cancer deaths were identified; 14
of the deaths occurred in subjects with HIV.
After adjusting for potentially confounding factors such as
age, sex, and smoking status, the researchers found HIV
infection was associated with a 3.6-fold increased risk for
lung cancer compared to HIV-negative status.
"As HIV-infected persons survive longer, we are continuing to
see that non-AIDS outcomes are becoming the primary causes of
morbidity and mortality. Our study suggests that the risks for
these non-AIDS outcomes may be modulated by HIV infection,"
Kirk said his team plans to combine its data with other HIV
and at-risk cohort studies to confirm the association between
HIV and lung cancer. "Also, we are evaluating a series of
smoking/tobacco related biomarkers in HIV-infected and
uninfected persons with similar smoking patterns to compare if
the biological effect of smoking differs by HIV status, and if
so, is this related to degree of immune suppression or to
antiretroviral treatment," he noted.
The study, "HIV Infection Is Associated with an Increased Risk
for Lung Cancer, Independent of Smoking," was published in
Clinical Infectious Diseases (2007;45(1):103-110).