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Expression of zeta molecules is decreased in NK cells from HIV-infected patients.
Geertsma MF; Stevenhagen A; van Dam EM; Nibbering PH; Department
March 30, 2000
FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):249-57. Unique Identifier :

Cytolysis by natural killer (NK) cells is impaired in HIV infection. We investigated whether the expression of zeta (zeta) molecules, essential elements of signalling initiated upon ligation of, e.g., CD16, is reduced and if so, whether this reduction could be involved in defective cytolysis. FACS analysis revealed significantly lower levels of zeta in NK cells from AIDS patients compared to cells from patients without AIDS and healthy controls. CD16-dependent cytolysis by NK cells correlated with expression of zeta molecules and CD16, the latter possibly related to zeta expression. No correlation was observed between CD16-independent cytolysis and zeta expression. Reduced expression of zeta molecules by NK cells from HIV-infected patients thus correlates with disease progression and may, in part, explain the defective cytolysis by these cells.

JOURNAL ARTICLE Adult Aged Antibodies, Monoclonal/IMMUNOLOGY Antibody-Dependent Cell Cytotoxicity Female Flow Cytometry Human HIV Infections/*IMMUNOLOGY/VIROLOGY HIV-1/GENETICS/*PHYSIOLOGY Killer Cells, Natural/*IMMUNOLOGY/*METABOLISM Male Membrane Proteins/IMMUNOLOGY/*METABOLISM Middle Age Receptors, Antigen, T-Cell/IMMUNOLOGY/*METABOLISM Receptors, IgG/IMMUNOLOGY/*METABOLISM Viral Load

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