FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):243-7. Unique Identifier :
The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have
been shown to serve as coreceptors for HIV-1 entry into macrophages.
Individuals that are homozygous for a defective CCR5 allele (DeltaCCR5)
are highly, but not fully, resistant to infection with HIV-1. Here, we
want to emphasize the importance of DeltaCCR5 in in vitro as well as in
vivo studies. We provide data that suggest that CCR5 polymorphism may
affect the onset of AIDS dementia complex in vivo and data that show
that HIV-1 replication is influenced by the DeltaCCR5 allele in vitro.
Knowing the CCR5 genotype of an individual will help to better interpret
research results and may even provide new information about mechanisms
JOURNAL ARTICLE AIDS Dementia Complex/*ETIOLOGY/GENETICS/VIROLOGY Gene
Products, tat/METABOLISM Genotype Heterozygote Human
HIV-1/*PHYSIOLOGY Macrophages/VIROLOGY Polymerase Chain Reaction
*Polymorphism (Genetics) Receptors, CCR5/*GENETICS RNA, Viral/ANALYSIS
Support, Non-U.S. Gov't Virus Replication