translation agency

Potential role of CCR5 polymorphism in the development of AIDS dementia complex.
Boven LA; van der Bruggen T; Sweder van Asbeck B; Marx JJ; Nottet HS;
March 30, 2000
FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):243-7. Unique Identifier :

The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (DeltaCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of DeltaCCR5 in in vitro as well as in vivo studies. We provide data that suggest that CCR5 polymorphism may affect the onset of AIDS dementia complex in vivo and data that show that HIV-1 replication is influenced by the DeltaCCR5 allele in vitro. Knowing the CCR5 genotype of an individual will help to better interpret research results and may even provide new information about mechanisms of disease.

JOURNAL ARTICLE AIDS Dementia Complex/*ETIOLOGY/GENETICS/VIROLOGY Gene Products, tat/METABOLISM Genotype Heterozygote Human HIV-1/*PHYSIOLOGY Macrophages/VIROLOGY Polymerase Chain Reaction *Polymorphism (Genetics) Receptors, CCR5/*GENETICS RNA, Viral/ANALYSIS Support, Non-U.S. Gov't Virus Replication