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Plasma HIV-1 RNA quantitation in HIV infected adult Zimbabweans.
Chaka WS; Sibanda EN; University of Zimbabwe Medical School, Harare,
December 30, 2000
Cent Afr J Med. 1999 Sep;45(9):231-4. Unique Identifier : AIDSLINE

OBJECTIVES: To determine HIV-1 RNA levels in plasma of HIV infected Zimbabwean adults and to correlate these with CD4+ cell counts. DESIGN: Prospective observational study. SETTING: Specialist Immunology Laboratory, Harare, Zimbabwe. SUBJECTS: 49 consecutive HIV infected patients. MAIN OUTCOME MEASURES: CD4+ cell counts and plasma HIV-1 RNA levels. RESULTS: Based on the CDC HIV classification system five patients were in early stage infection, 15 in middle, 17 in late and 12 in advanced stage of infection. The median CD4+ cell count was 165/microL (Q1 = 4; Q3 = 866). The median HIV-1 RNA levels were 73,097 RNA copies/ml (Q1 = 753; Q3 = 750,000). Eighty percent of the patients had HIV-1 RNA levels > 10,000 copies/ml and 49% had > 100,000 RNA copies/ml. Median viral loads among the four categories of infection were found to be highly significant (p < 0.001). The correlation between CD4+ cell counts and HIV-1 RNA copies for the 49 patients was highly significant (r = -0.76; p < 0.001). CONCLUSIONS: High treatment HIV-1 RNA levels were determined in the majority of patients. A highly significant correlation was obtained between plasma HIV-1 RNA levels and CD4+ cell counts.

JOURNAL ARTICLE Adult CD4 Lymphocyte Count Disease Progression Female Human HIV Infections/*BLOOD/CLASSIFICATION/IMMUNOLOGY/*VIROLOGY HIV-1/*GENETICS Male Middle Age Predictive Value of Tests Prospective Studies Regression Analysis Reproducibility of Results RNA, Viral/*BLOOD Severity of Illness Index *Viral Load Zimbabwe