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Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis.
Stromberg K; Benveniste RE; Arthur LO; Rabin H; Giddens WE Jr; Ochs HD;
July 30, 1984
Science. 1984 Apr 20;224(4646):289-2. Unique Identifier : AIDSLINE

A novel type D retrovirus was isolated by cocultivation of explants of fibromatous tissue from a rhesus monkey (Macaca mulatta) with immunodeficiency and retroperitoneal fibromatosis. This type D virus, isolated from a macaque with simian acquired immunodeficiency syndrome (SAIDS-D/Washington), is exogenous and is partially related to the Mason-Pfizer and the langur monkey type D viruses. The SAiDS-D virus can be distinguished from all other primate retroviruses by antigenicity and molecular hybridization. Nucleic acid hybridization studies reveal that the origin of the SAIDS-D isolate may reside in Old World monkey (subfamily Colobinae) cellular DNA.

Acquired Immunodeficiency Syndrome/MICROBIOLOGY/*VETERINARY Animal Antigenic Determinants Antigens, Viral/IMMUNOLOGY Base Sequence Cercopithecidae/GENETICS Comparative Study *Disease Models, Animal DNA, Viral Fibroma/MICROBIOLOGY/*VETERINARY Macaca mulatta/MICROBIOLOGY Monkey Diseases/*MICROBIOLOGY Nucleic Acid Hybridization Retroperitoneal Neoplasms/MICROBIOLOGY/*VETERINARY Retroviridae/CLASSIFICATION/*ISOLATION & PURIF/PHYSIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viral Envelope Proteins/IMMUNOLOGY Viral Proteins/IMMUNOLOGY JOURNAL ARTICLE