JAMA. 1985 Jun 21;253(23):3425-8. Unique Identifier : AIDSLINE
The most common manifestations of the acquired immunodeficiency syndrome
include Pneumocystis carinii pneumonia and/or Kaposi's sarcoma.
High-grade B-cell lymphomas have also been reported in homosexual men at
risk for the acquired immunodeficiency syndrome. We herein present the
case of a homosexual man, who presented simultaneously with Pneumocystis
carinii pneumonia, acute cytomegalovirus infection, Kaposi's sarcoma,
and B-cell immunoblastic sarcoma. Severe compromise of both the B- and
T-cell arms of the immune system was documented. The patient had
evidence of exposure to the human T-lymphotropic retrovirus III,
evidence of reactivation of Epstein-Barr virus infection, and
cytomegalovirus inclusions within Kaposi's sarcoma tissue. We conclude
that exposure to these viral agents in the setting of severe
immunocompromise may have led to the observed opportunistic neoplasms.
Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult B-Lymphocytes
Case Report Cytomegalovirus Infections/ETIOLOGY Cytotoxicity Tests,
Immunologic Flow Cytometry Homosexuality Human
Interleukin-2/BIOSYNTHESIS Killer Cells, Natural/IMMUNOLOGY
Lymphoma/*ETIOLOGY/IMMUNOLOGY Male Neoplasms, Multiple
Primary/ETIOLOGY Pneumonia, Pneumocystis carinii/ETIOLOGY Sarcoma,
Kaposi's/ETIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.