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Westin EH; Wong-Staal F; Gallo RC; Lab. of Tumor Cell Biology, NCI,
October 30, 1986
Cancer Treat Res; 26:1-25 1985. Unique Identifier : AIDSLINE

Retroviruses are of special importance in the understanding of the origin and pathogenesis of leukemias and lymphomas of man. Not only are they a major cause of naturally occurring leukemias and lymphomas in several animal species, thus providing useful model systems relating to the cause and development of neoplasias in man, but retroviruses also provide a means to identify and study some cellular genes (so-called onc genes) which are important in cell growth and differentiation and which have been transduced by the acutely transforming retroviruses. It is believed that abnormal expression and/or qualitative modification of the c-onc genes are involved in the molecular pathogenesis of most or even all cancers no matter what the cause. Retroviruses and onc genes in human leukemias and lymphomas are discussed under the following headings: onc genes in leukemogenesis (retroviral derived cellular onc genes; potential transformation genes detected by transfection techniques), and retroviruses in human leukemia-lymphoma (background considerations; growth of mature human T-cells growth factor (TCGF) and the isolation of the first human retroviruses (HTLV); seroepidemiology of HTLV; molecular epidemiology of HTLV-related diseases; in vitro transformation of normal cord blood T-cells by HTLV; possible mechanisms for HTLV transformation). (97 refs)

Animal Antibodies, Viral/ANALYSIS Bibliography Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Gene Amplification Gene Expression Regulation Human HTLV-BLV Viruses/GENETICS/IMMUNOLOGY Leukemia/*GENETICS Lymphoma/*GENETICS *Oncogenes Retroviridae/GENETICS Retroviridae Infections/*GENETICS T-Lymphocytes/MICROBIOLOGY Transformation, Genetic BIBLIOGRAPHY JOURNAL ARTICLE