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Primary central nervous system lymphoma related to Epstein-Barr virus in a patient with acquired immune deficiency syndrome.
Rosenberg NL; Hochberg FH; Miller G; Kleinschmidt-DeMasters BK
November 30, 1986
Ann Neurol. 1986 Jul;20(1):98-102. Unique Identifier : AIDSLINE

The study of a patient suggested a relationship between Epstein-Barr virus infection and primary lymphoma of the central nervous system in the acquired immune deficiency syndrome. Deoxyribonucleic acid preparations from tumor tissue contained 30 to 100 copies of Epstein-Barr virus genome per cell when hybridized with a probe consisting of the Bam-HI K fragment of Epstein-Barr virus strain FF41. This hybridization study suggests that induction of this patient's central nervous system lymphoma was related to Epstein-Barr virus infection.

Acquired Immunodeficiency Syndrome/*COMPLICATIONS Brain Neoplasms/ANALYSIS/*COMPLICATIONS Case Report DNA, Viral/ANALYSIS Herpesvirus 4, Human Human Lymphoma, Non-Hodgkin's/ANALYSIS/*COMPLICATIONS Male Middle Age *Occipital Lobe Tumor Virus Infections/*COMPLICATIONS JOURNAL ARTICLE