Cell. 1986 Aug 1;46(3):401-5. Unique Identifier : AIDSLINE MED/86272087
Interleukin-2 (IL-2) is a lymphokine that plays a crucial role in the
immune system, especially in the growth control of T lymphocytes.
Expression of this lymphokine is restricted to activated T lymphocytes.
Here we demonstrate the presence of unique DNA sequences in the 5'
flanking region of the human IL-2 gene that control induced
T-cell-specific gene expression. We also show that the DNA sequences
function in an orientation-independent manner and activate a
heterologous promoter which is otherwise inert in induced T cells. The
DNA, which spans about 200 bp, contains regions with sequence homology
to LTR sequences of HTLV-III (or LAV) and the 5' upstream region of the
IL-2 receptor and interferon-gamma genes.
Base Sequence Cell Line DNA/*GENETICS Enhancer Elements (Genetics)
*Gene Expression Regulation Genes, Synthetic Human HTLV-BLV
Viruses/GENETICS Interleukin-2/BIOSYNTHESIS/*GENETICS Lymphocyte
Transformation Promoter Regions (Genetics) Sequence Homology, Nucleic
Acid Support, Non-U.S. Gov't T-Lymphocytes/METABOLISM JOURNAL ARTICLE