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Abnormal B-cell function in hemophiliacs treated with cryoprecipitate and factor VIII and IX concentrates.
Gorski A; Gjerset GF; Martin PJ; Counts RB; Hansen JA
November 30, 1986
Clin Immunol Immunopathol. 1986 Sep;40(3):447-55. Unique Identifier :

B-Cell function was evaluated in a group of 43 patients with factor VIII or factor IX deficiency. Thirty had been treated primarily with cryoprecipitate and 13 with concentrates of factor VIII or IX. Serum immunoglobulin G levels were found to be diffusely elevated; however, the absolute number of mature B cells in peripheral blood was normal. B-Cell function as measured by testing mitogen-induced proliferation and and immunoglobulin secretion by plaque-forming cells (PFC) in vitro was reduced. Coculture experiments suggested that these abnormal B-cell responses might be secondary to increased suppressor T-cell activity, which was found more frequently in patients seropositive for antibody to lymphadenopathy-associated virus. Both seronegative and seropositive patients had reduced responses in the proliferative and PFC assays, but the lowest PFC responses occurred in the seropositive group.

Adolescence Adult Aged B-Lymphocytes/*IMMUNOLOGY Child Christmas Disease/IMMUNOLOGY Factor IX/*THERAPEUTIC USE Factor VIII/*THERAPEUTIC USE Fibrinogen/*THERAPEUTIC USE Hemolytic Plaque Technique Hemophilia/DRUG THERAPY/*IMMUNOLOGY Human IgG/ANALYSIS Middle Age Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE