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NLM AIDSLINE
Spastic paraparesis and HTLV-I infection in Peru.
Johnson RT; Griffin DE; Arregui A; Mora C; Gibbs CJ Jr; Cuba JM; Trelles
June 30, 1988
Ann Neurol. 1988;23 Suppl:S151-5. Unique Identifier : AIDSLINE

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T-helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.

Adult Aged Antibodies, Viral/ANALYSIS/CEREBROSPINAL FLUID Blood Cells/PATHOLOGY Case Report Cell Division Female Human *HTLV-BLV Infections/CEREBROSPINAL FLUID/IMMUNOLOGY/PATHOLOGY Leukocytes, Mononuclear/PATHOLOGY Male Middle Age Muscle Spasticity/CEREBROSPINAL FLUID/ETIOLOGY/IMMUNOLOGY/ PATHOLOGY Myelitis/ETIOLOGY Paraplegia/CEREBROSPINAL FLUID/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY Peru Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

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