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NLM AIDSLINE
Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs.
Jackson JB; Kwok SY; Hopsicker JS; Sannerud KJ; Sninsky JJ; Edson JR;
June 30, 1989
Transfusion. 1989 Mar-Apr;29(3):265-7. Unique Identifier : AIDSLINE

In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected individuals is probably very low.

Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*PSYCHOLOGY/ TRANSMISSION Adult Female Hemophilia/COMPLICATIONS/*PSYCHOLOGY Human HIV Antibodies/ANALYSIS HIV Seropositivity/DIAGNOSIS/EPIDEMIOLOGY/*PSYCHOLOGY *HIV-1 Middle Age *Sexual Partners Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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