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Natural history of AIDS in children of African origin seen in Belgium: evidence for two patterns.
Jonckheer T; Levy J; Alimenti A; Francois A; Ninane J; Institute of
September 30, 1990
Int Conf AIDS. 1989 Jun 4-9;5:319 (abstract no. T.B.P.197). Unique

OBJECTIVE: To describe the diseases indicative of AIDS in children of African origin seen in Belgium. METHODS: The children of African origin with at least one disease indicative of AIDS according to the latest CDC-case definition were selected. RESULTS: Forty-four children met the inclusion criteria (male/female ratio = 1). Three (7%) had a history of blood transfusion in Africa, the others were presumed to be born to an HIV infected mother. Following diseases indicative of AIDS were diagnosed: bacterial infections (n = 24), LIP/PLH complex (23), PCP (10), HIV encephalopathy (9), Candida albicans (5), herpes simplex (1), disseminated BCG (1), HIV wasting syndrome (1), HIV related cancers (1). Thirteen children (23%) are known to have died, 9/13 before the age of 12 months, all the others (4/13) after the age of 78 months. Thirty-one (77 %) were still alive when last seen (mean age 36 months, median 29 months, range 5-104 months). Twenty children (45 %) had only LIP/PLH complex and/or bacterial infections when last seen (mean age 48 months, median 44,5 months, range 8-103 months, mode 40-49 months), whereas 24 children (55 %) had true opportunistic infections and/or HIV encephalopathy and/or HIV related cancers when last seen (mean age 29 months, median 11.5 months, range 4-126 months, mode 0-9 months). CONCLUSIONS: Our data suggest that the natural history of HIV infection in African children is characterized by at least two patterns: one group of infants and younger children with rapid onset, a more severe expression of the disease and poor prognosis, and a second group of older children with later onset, a more chronic expression (only LIP/PLH complex and/or bacterial infections) but with potential poor prognosis after several years of evolution.

Acquired Immunodeficiency Syndrome/DIAGNOSIS/*EPIDEMIOLOGY Africa/ETHNOLOGY Belgium/EPIDEMIOLOGY Centers for Disease Control and Prevention (U.S.) Child Child, Preschool Female Human Infant Male Neoplasms/COMPLICATIONS/DIAGNOSIS Opportunistic Infections/COMPLICATIONS/DIAGNOSIS/MORTALITY Prognosis ABSTRACT