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Asymptomatic HIV-1 seropositive hemophiliac children have no evidence of CNS dysfunction detected by neurologic, MRI or clinical neurophysiologic assessment.
Tennison M; Messenheimer J; Ehle A; Hall C; Whitt J; University of North
December 30, 1990
Int Conf AIDS. 1990 Jun 20-23;6(2):435 (abstract no. 3134). Unique

OBJECTIVE: To define by extensive neurologic, radiographic and clinical neurophysiologic assessment the incidence and features of any CNS deficits which may be present in asymptomatic HIV-1 seropositive hemophiliac children including evidence of subclinical CNS dysfunction before overt symptoms are present. METHODS: All patients (106) seen in a comprehensive hemophilia center were recruited for the study. 22 seronegative and 8 seropositive patients refused entry. 5 patients died before the study started. To date, 23 Seropositive (all asymptomatic) and 37 seronegative patients have been studied. Detailed neurologic exam, EEG, quantitative EEG, evoked potential battery (Visual, somatosensory and auditory) and MRI scans were performed. All studies were scored by blinded observers. Group differences were evaluated with the Yates corrected chi square and/or paired t-test comparing seropositive subjects with one or more age-matched control seronegative subjects. RESULTS: There were no significant differences between patients seropositive and seronegative at the p less than .05 level on any of the study parameters. CONCLUSION: Despite the observation in adults of laboratory evidence of CNS infection with HIV-1 from the time of seroconversion, we found that intensive neurologic investigation in asymptomatic hemophiliac children fails to detect signs of CNS dysfunction. This finding is encouraging regarding prospects for continued neurologic well-being and may be an important factor in planning future treatment strategies for these children.

Central Nervous System Diseases/*COMPLICATIONS/EPIDEMIOLOGY Electroencephalography Evoked Potentials Hemophilia/*COMPLICATIONS Human HIV Seropositivity/*COMPLICATIONS Incidence Magnetic Resonance Imaging Neurologic Examination ABSTRACT