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Zidovudine treatment in HIV-infected intravenous drug users. Compliance with long-term treatment and efficacy.
Del Bono V; Mazzarello G; Anselmo M; Canessa A; Terragna A; Department
December 30, 1990
Int Conf AIDS. 1990 Jun 20-23;6(3):198 (abstract no. S.B.450). Unique

OBJECTIVE: To assess the compliance with long-term zidovudine treatment and the efficacy of therapy in a cohort of intravenous drug users (IVDUs). METHODS: Eighty-six HIV-infected IVDUs were treated with oral zidovudine for 3-24 months in an outpatient setting. A retrospective, historical control group of 127 IVDUs was selected according to disease staging. RESULTS: Cumulative probability of voluntary zidovudine discontinuation was 9% at 3 months, 29% at 6 months, and 38% at 9 months. No more drop outs occurred after 9 months of treatment. Monitoring of mean corpuscolar volume of red blood cells well correlated with time of treatment. Patients receiving zidovudine showed a cumulative probability of survival at 12 months of 88+/-9.8%, as compared with 50+/-8.6% in untreated patients (P less than 0.001). Less opportunistic infections occurred among zidovudine treated subjects than among untreated patients (4 vs. 15, respectively, after 12 months; P less than 0.001). Marrow toxicity was the most relevant toxic effect observed. CONCLUSION: Acceptable rates of compliance with long-term zidovudine treatment are attainable in IVDUs. Survival data and incidence of opportunistic infections show that HIV-infected IVDUs can benefit from continued zidovudine treatment.

Bone Marrow Diseases/CHEMICALLY INDUCED/COMPLICATIONS Human HIV Infections/*DRUG THERAPY/EPIDEMIOLOGY Incidence Italy/EPIDEMIOLOGY Longitudinal Studies Opportunistic Infections/COMPLICATIONS/DRUG THERAPY Outpatients *Patient Compliance Retrospective Studies *Substance Abuse, Intravenous/COMPLICATIONS Survival Analysis Zidovudine/ADVERSE EFFECTS/PHARMACOLOGY/*THERAPEUTIC USE ABSTRACT