Int Conf AIDS. 1990 Jun 20-23;6(3):189 (abstract no. S.B.413). Unique
OBJECTIVE: Non-specific interstitial pneumonitis (NSIP) has been
reported to occur in 13-38% of AIDS patients. The present study was
designed to ascertain: 1) whether the nature and incidence of pulmonary
complications is changing; 2) does NSIP occur with the recently reported
high frequency. METHODS: Between 3/88 and 12/89, 207 consecutive
HIV+/AIDS patients who presented with fever, dyspnea and an abnormal
chest x-ray underwent bronchoscopy with transbronchial biopsy and lavage
(168) or sole lavage (39). RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME.
In addition, there were 2 cases of pulmonary lymphoma and 1 carcinoma.
Ten patients (5%) had negative biopsies and/or lavage; CMV (6) or MTB
(4) were found elsewhere and chest radiographs improved with therapy.
There were 7 (4%) non-diagnostic bronchoscopies; all patients improved
without therapy. Of the 31 patients with NSIP, 15 had previous pulmonary
opportunistic infections or known pulmonary KS. Thus, only 16 (8%) had
true NSIP without explicable causes. CONCLUSION: 1) PCP remains the most
common pulmonary complication. 2) The relative incidence of pulmonary
complications is similar to previous published reports. 3) In contrast
to recent reports, NSIP does not occur with increasing frequency. When
all known causes are excluded, it occurred in 8% of patients in the
Acquired Immunodeficiency Syndrome/*COMPLICATIONS/RADIOGRAPHY Human
Incidence Lung Diseases/*COMPLICATIONS/RADIOGRAPHY Opportunistic
Infections/COMPLICATIONS/RADIOGRAPHY Pneumonia, Pneumocystis
carinii/RADIOGRAPHY Sarcoma, Kaposi's/ETIOLOGY/RADIOGRAPHY Thoracic