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NLM AIDSLINE
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
Snoeck R; Lagneaux L; Delforge A; Bron D; Van der Auwera P; Stryckmans
January 30, 1991
Eur J Clin Microbiol Infect Dis. 1990 Aug;9(8):615-9. Unique Identifier

Phosphonoformate, ganciclovir, zidovudine and the novel acyclic nucleotide analogues (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were evaluated for their inhibitory effect on colony forming unit formation by human granulocyte-macrophage progenitor cells (obtained from 11 healthy volunteers) in vitro. The 50% inhibitory dose of zidovudine, (S)-HPMPA, (S)-HPMPC, ganciclovir and phosphonoformate were 10.61, 16.55, 80.88, 41.02 and 668.64 microM, respectively, when the median-effect principle was applied. The bone marrow toxicity of zidovudine used at a low concentration (3.74 microM) was significantly decreased if the drug was combined with (S)-HPMPA, (S)-HPMPC or ganciclovir. If used at higher concentrations (74.90 microM), zidovudine showed increased myelotoxicity in the presence of (S)-HPMPA and ganciclovir, but not (S)-HPMPC.

Adenine/ANALOGS & DERIVATIVES/PHARMACOLOGY Adult Antiviral Agents/*PHARMACOLOGY Bone Marrow/CYTOLOGY/DRUG EFFECTS Cells, Cultured Cytomegalovirus/*DRUG EFFECTS Cytosine/ANALOGS & DERIVATIVES/PHARMACOLOGY Ganciclovir/PHARMACOLOGY Granulocytes/DRUG EFFECTS Hematopoietic Stem Cells/*DRUG EFFECTS Human HIV/*DRUG EFFECTS Macrophages/DRUG EFFECTS Organophosphorus Compounds/PHARMACOLOGY Phosphonoacetic Acid/ANALOGS & DERIVATIVES/PHARMACOLOGY Support, Non-U.S. Gov't Zidovudine/PHARMACOLOGY JOURNAL ARTICLE

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