AJNR Am J Neuroradiol. 1990 Sep-Oct;11(5):905-11; discussion 912-3.
The ability of MR to detect CNS lesions in AIDS patients was evaluated
by postmortem scanning of 10 formalin-fixed brains. Nine patients had
premortem mental status changes and five had focal neurologic deficits.
The brains were imaged and sectioned in corresponding planes. MR images
showed atrophy in eight of the 10. All grossly identified lesions and
areas of MR abnormality were histologically evaluated. Areas of
infarction and necrosis associated with cytomegalovirus (CMV) or
Toxoplasma gondii were seen as foci of increased signal intensity.
Severe ventriculitis and focal gliosis were also visible by MR. Neither
CT nor MR was able to detect diffuse CMV- or HIV-associated microglial
nodules. Dementia without focal neurologic signs correlated best with
the presence of diffuse microglial nodules at pathology. Our results
demonstrate the usefulness of correlating postmortem MR imaging with
neuropathology, and the relevance of postmortem findings to the
interpretation of MR images in living patients.
Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY/
RADIOGRAPHY Adult Atrophy/PATHOLOGY Brain/*PATHOLOGY/RADIOGRAPHY
Brain Diseases/ETIOLOGY/*PATHOLOGY/RADIOGRAPHY False Negative Reactions
False Positive Reactions Human *Magnetic Resonance Imaging Male
Middle Age Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Tomography, X-Ray Computed JOURNAL ARTICLE