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Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.
Terai C; Kornbluth RS; Pauza CD; Richman DD; Carson DA; Department of
August 30, 1991
J Clin Invest. 1991 May;87(5):1710-5. Unique Identifier : AIDSLINE

The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed cell death pathway that may regulate both T cell development and senescence, and that is characterized by cleavage of DNA at internucleosomal regions. The present experiments show that acute HIV-1 infection of MT2 lymphoblasts and activated normal peripheral blood mononuclear cells induces apoptosis. The addition of anti-gp120 neutralizing antibody, after HIV-1 infection of MT2 cells, permitted sustained high levels of viral replication, but blocked apoptosis and cell death. Apoptosis may account for the direct cytopathologic effects of HIV-1 in T cells.

Antigens, CD4/PHYSIOLOGY Calcium/METABOLISM *Cell Survival Cells, Cultured DNA/METABOLISM Human HIV Envelope Protein gp120/METABOLISM HIV Infections/PATHOLOGY *HIV-1/PHYSIOLOGY Nucleosomes/METABOLISM Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. T-Lymphocytes/MICROBIOLOGY/*PATHOLOGY JOURNAL ARTICLE