J Med Primatol. 1991 Jun;20(4):201-5. Unique Identifier : AIDSLINE
We investigated the role of Interleukin-6 (IL-6) as an autocrine growth
factor for the retroperitoneal fibromatosis (RF) cells present in
macaques infected with the simian retrovirus type 2 (SRV-2). Elevated
levels of IL-6 were found in serum of SRV-2 antibody-positive macaques,
ascites from RF-positive animals, and RF cell line culture media. IL-6
mRNA levels increased approximately five-fold in RF cells incubated with
exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and
protein production and presumably serves as autocrine growth factor.
Animal Cell Line Culture Media Enzyme-Linked Immunosorbent Assay
Interleukin-6/*ANALYSIS/BLOOD/GENETICS Macaca nemestrina Polymerase
Chain Reaction Retroperitoneal Neoplasms/*COMPLICATIONS Retroviruses
Type D, Simian/*IMMUNOLOGY RNA, Messenger/ANALYSIS Simian Acquired
Immunodeficiency Syndrome/*COMPLICATIONS Support, U.S. Gov't, P.H.S.