J Theor Biol. 1992 Feb 7;154(3):285-302. Unique Identifier : AIDSLINE
The human T-lymphotropic retroviruses HTLV-I and HIV-1/-2 share a
complementary patchwork homology in which the RRE regions of HIV-1 and
-2 cover 78.1% of a 169 nucleotide (nt) region (PX1,2) positioned
precisely between open reading frames PX I and PX II of ATLV (HTLV-I).
The sequence character of the PX1,2 region is shown to be influenced by
a primordial expansion, CTC2T, originating several hundred nucleotides
upstream. A second primordial expansion, AGCU(U/C), is identified and
shown to represent 52.1% of the HIV-1 RRE region. It is argued that
prior to the present AIDS pandemic the efficiency of the rev receptor
was enhanced by an ancestral recombination event.
Base Sequence *Evolution Genes, Viral/*GENETICS HIV-1/*GENETICS
HIV-2/GENETICS HTLV-BLV Viruses/GENETICS *Models, Genetic Molecular
Sequence Data Recombination, Genetic Sequence Homology, Nucleic Acid