Int Conf AIDS. 1992 Jul 19-24;8(3):64 (abstract no. PuB 7090). Unique
OBJECTIVES: To evaluate the incidence, evolution and main
epidemiological, clinical and pathological characteristics of
lymphoproliferative disorders (LPD) in AIDS patients. METHODS:
Retrospective analysis of 480 AIDS patients (85% male) diagnosed and
controlled in our Hospital during a period of 81 month (Apr 84-Jan 92).
The AIDS risk groups were: IVDU 58%, Homosexual 22%. RESULTS: 39
patients (37 male, mean age: 33 y) developed a LPD. Of them 33 were
non-Hodgkin lymphomas (NHL) (20 High grade, 7 Burkitt type; 7 Primary
Central Nervous System (CNS); 2 Castleman-like disease), and 6 were
Hodgkin diseases (HD). NHL was the AIDS-diagnosing condition in 21 cases
(64%). All but one HD occurred in HIV infected patients before the
appearance of an AIDS-diagnosing condition. Non-Hodgkin lymphomas: 33
patients (31 males, mean age: 33 y). AIDS risk groups: IVDU 40%,
Homosexual 45%. 16 patients (50%) were in clinical stage IV at
diagnosis, and extranodal involvement was present in 24 (7 primary CNS).
Twenty-eight patients were treated with chemotherapy, of them 4 also
received radiotherapy. Twenty-eight (85%) patients died related to LPD.
Overall survival period was 5 month (1-31). Hodgkin disease: 6 patients
(all males, mean age: 29 y). AIDS risk groups = 66% IVDU, 33%
Homosexuals. Five patients were in stage IV with extranodal involvement
at diagnosis. All but one patient were treated with chemotherapy. Five
patients are alive with a mean survival period of 30 months (2-63).
CONCLUSIONS: 1) The incidence of LPD was 8.1% in our series of AIDS
patients, with a ratio NHL/HD of 5.5. 2) The LPD was the AIDS-defining
condition in 21 cases (64%). 3) Patients with HD had the better
prognosis (p less than 0.05), while Primary CNS lymphoma had the
poorest. 4) LPD in AIDS patients behaves more aggressively than in non
HIV-infected patients, with frequent extranodal involvement, advanced
stage at diagnosis and fatal evolution.
Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Female Human
Lymphoproliferative Disorders/*COMPLICATIONS Male Retrospective