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Computer studies on HIV-1 proteins: identification of initial sites.
Zagury JF; Cantalloube H; Callebaut I; Burny A; Mornon JP; Zagury D;
December 30, 1992
Int Conf AIDS. 1992 Jul 19-24;8(3):44 (abstract no. PuA 6199). Unique

OBJECTIVE: To determine significant similitudes between HIV-1 proteins and other known proteins in order to explain some of HIV-1 disorders. METHODS: We worked on a VAX-VMS system and we used the MIPS data bank which contains more than 45,000 protein sequences. RESULTS: We have designed 2 softwares: one is able to screen the whole data bank for significant homologies with a given sequence; the other one gives an evaluation on the biological significance of the homologies found. We applied these softwares on HIV-1 proteins, especially the envelope. Using these 2 softwares, we have found numerous homologies between HIV-1 and proteins in the MIPS data bank, which were not selected by other classical screening programs. We also looked for homologies in HIV-2 and other envelope viruses. The similitudes found concern many proteins involved in immune T-cell regulation, which gives rise to possible explanations for HIV-1-induced immune impairment. CONCLUSION: Implications in the physiopathology of AIDS disease, and for the development of therapeutic strategies.

Acquired Immunodeficiency Syndrome/PHYSIOPATHOLOGY/THERAPY Amino Acid Sequence Comparative Study *Databases, Factual Human HIV-1/*GENETICS Sequence Homology, Nucleic Acid Software Viral Envelope Proteins/CHEMISTRY/GENETICS Viral Proteins/*CHEMISTRY/GENETICS ABSTRACT