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Rapid development of symptomatic HIV-1 related disease in prostitutes in Nairobi, Kenya.
Anzala AO; Plummer FA; Ngugi EN; Emonyi W; Kreiss JK; Ndiny-Achola JO;
December 30, 1992
Int Conf AIDS. 1992 Jul 19-24;8(2):C303 (abstract no. PoC 4353). Unique

OBJECTIVE: This study was designed to determine the incubation period and risks for development of HIV-1 related disease in a population of women with a known time of seroconversion. METHOD: A cohort of 163 women were enrolled at the time of seroconversion and followed for the occurrence of HIV-1 related illness at 6 months intervals for 12-60 months following seroconversion. Survival analysis were performed. HIV-1 related disease was classified using the CDC staging system. Lymphocyte subset determination were performed by flow cytometry. RESULTS: Of the 163 women identified 68 have developed stage 4A disease while 57 have developed stage 4C disease. The median time to development of stage 4A was 47.3 months with a mean time of 67.2 months. The median time to development of stage 4C disease was 51.1 months with a mean time of 86.3 months. Lymphocyte subset determination showed a close correlation between clinical staging and absolute CD4 counts. CONCLUSION: The incubation time to symptomatic disease is much shorter in this cohort of women as compared to other studies. This may have profound impacts on the course of the HIV epidemic in Africa.

Cohort Studies CD4-Positive T-Lymphocytes Female Human HIV Infections/*DIAGNOSIS/MORTALITY HIV Seropositivity/*COMPLICATIONS *HIV-1 Kenya/EPIDEMIOLOGY Leukocyte Count Lymphocyte Subsets *Prostitution Survival Analysis Time Factors ABSTRACT