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Elevated serum parathyroid hormone related protein and 1,25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemia-lymphoma.
Johnston SR; Hammond PJ; Department of Medicine, Royal Postgraduate
April 30, 1993
Postgrad Med J. 1992 Sep;68(803):753-5. Unique Identifier : AIDSLINE

Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), which is associated with hypercalcaemia of several solid malignancies, were demonstrated in a patient with ATLL hypercalcaemia. Treatment with bisphosphonates reduced the serum calcium but had no significant effect on the serum PTHrP levels. This case supports recent in vitro evidence for enhanced PTHrP expression in ATLL tumour cells and suggests that more than one tumour cell product may be involved in the pathogenesis of ATLL hypercalcaemia.

Calcitriol/*BLOOD Case Report Female Human Hypercalcemia/*BLOOD/ETIOLOGY Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*BLOOD/ COMPLICATIONS Middle Age Neoplasm Proteins/*BLOOD Proteins/*ANALYSIS JOURNAL ARTICLE