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Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats.
Reubel GH; George JW; Barlough JE; Higgins J; Grant CK; Pedersen NC;
May 30, 1993
Vet Immunol Immunopathol. 1992 Dec;35(1-2):95-119. Unique Identifier :

Cats with or without chronic feline immunodeficiency virus (FIV) infection were exposed to feline herpesvirus, type 1 (FHV-1). FIV infected cats became sicker than non-FIV infected cats and required more supportive treatment. However, there were no differences in the length of their illness or in the levels and duration of FHV-1 shedding. FHV-1 infection caused a transient neutrophilia at Day 7 with a rapid return to preinfection levels. The neutrophilia coincided with a transient lymphopenia that was accompanied by a decline in both CD4+ and CD8+ T-lymphocytes. A brief decrease in the CD4+/CD8+ T-lymphocyte ratio occurred at Day 14 in both FIV infected and non-infected cats. This decrease was mainly the result of an absolute and transient increase in CD8+ T-lymphocytes. CD4+ and CD8+ T-lymphocyte numbers and CD4+/CD8+ T-lymphocyte ratios returned to baseline within 4-8 weeks in both FIV infected and non-infected cats. FIV infected cats produced less FHV-1 neutralizing antibodies during the first 3 weeks of infection than non-FIV infected animals. The IgM FHV-1 antibody response was depressed in FIV infected cats whereas the IgG antibody response was unaffected. FHV-1 infection evoked a comparable transient loss of lymphocyte blastogenic responses to concanavalin A and pokeweed mitogen in both FIV infected and non-infected cats. However, response to pokeweed mitogen took longer to return to normal in FIV infected animals. Lymphocytes from FIV infected cats had a greater and more sustained proliferative response to FHV-1 antigen than non-FIV infected cats. The ongoing IgG antibody response to FIV was not affected by FHV-1 infection.

Acute Disease Animal Antibodies, Viral/BIOSYNTHESIS Cats Chronic Disease CD4-CD8 Ratio CD4-Positive T-Lymphocytes/IMMUNOLOGY Feline Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS/ IMMUNOLOGY Female Herpesviridae/*IMMUNOLOGY/ISOLATION & PURIF Herpesviridae Infections/BLOOD/*COMPLICATIONS/IMMUNOLOGY Immunodeficiency Virus, Feline/*IMMUNOLOGY/ISOLATION & PURIF Lymphocyte Transformation/IMMUNOLOGY Lymphopenia Male Neutropenia Specific Pathogen-Free Organisms Support, U.S. Gov't, P.H.S. T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY Virus Shedding JOURNAL ARTICLE