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NLM AIDSLINE
Phylogenetic and geographical analysis of HTLV-1/STLV-1 in the world.
Miura T; Igarashi T; Yamashita M; Ido E; Hayami M; Inst. Virus Research,
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):269 (abstract no. PO-A34-0810). Unique

OBJECTIVE: Some new isolates including those from Gabon, Ghana, India and AINU people in Japan were genomically analysed and compared phylogenetically with other HTLV-1/STLV-1 reported previously. METHODS: Phylogenetic tree was constructed by use of nucleotide sequences of the part of LTR. RESULTS: There are 5 groups of HTLV-1 (A, B, C, D and E) in human. Group A consists of Caribbean, Indian and Japanese isolates including that from AINU people, and group B consists of almost Japanese isolates except for one Indian isolate, suggesting that there are two ancestral lineages of the Japanese HTLV-1 and one of them (group A) was brought to Caribbean basin. Group C consists of the West African and Caribbean isolates, indicating that the part, not all, of Caribbean strain directly originated from West Africa. Group D consists of the isolates from central region of Africa and made one cluster together with STLV-1 from chimpanzee, suggesting the interspecies transmission between human and non-human primate in the past. Group E consists of melanesian isolates which diverged at the earlist among the groups. There is no specific clustering linked to the pathogenicity, such as ATL and HAM/TSP. CONCLUSION: The topology of the phylogenetic tree of this virus may reflect the movement of the people who had the virus in the past.

*HTLV-I/GENETICS *Phylogeny *STLV/GENETICS

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