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Successive single gestation pregnancies and the course of HIV disease in mothers.
Wiley D; Abadie M; Van Dyke R; Gaumer R; Robinson W; Tulane University
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):457 (abstract no. PO-B23-1933). Unique

PURPOSE: To determine the effect of successive single gestation pregnancies after HIV infection on the progression of HIV disease in mothers. METHODS: Records for 14 women with more than one pregnancy since being diagnosed HIV positive were examined retrospectively. Each woman was retrospectively matched case-by-case with a woman who had delivered once since being diagnosed; patients were matched for age, date of diagnosis and date of first delivery. RESULTS: 14 women (avg. age 23, control group, 23) were pregnant 32 times (28 live births, 4 abortions), for an average of 2.2 pregnancies per woman (range 2-4 pregnancies). No maternal AIDS-defining OI's or fatalities have been reported to date in either group. 7 women (50%) in the study group were treated with antiretrovirals (5 ZDV, 1 ddI, 1 placebo or ZDV); 8 women (57%) in the control group were treated with antiretrovirals (7 ZDV, 1 placebo or ZDV). Duration of HIV positivity has averaged 37 months for both groups. CD4 counts measured at comparable times post-diagnosis averaged 460/mm3 range 260-790/mm3) with CD4% averaging 26% (range 17-36) for the study group, while CD4 counts measured in the control group at the same time post-diagnosis averaged 638/mm3 (range 345-1290/mm3) with CD4% averaging 28% (range 13-49). CONCLUSIONS: These data suggest that the progression of HIV disease might be accelerated by successive single gestation pregnancies, as evidenced by the decreased CD4 counts and percentages in those mothers who have been pregnant at least twice during the course of their HIV disease. Further studies appear warranted.

*HIV Infections/COMPLICATIONS *Pregnancy Complications, Infectious/ETIOLOGY