Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in AIDS patients with frequent recurrences. We administered in 157 adults (145 males, 12 females) with AIDS, CD4 < 200 and under zidovudine either trimethoprime/sulfamethoxazole (TMP/SMX) 800/160 mg/day, or 300 mg of aerolized pendamidine/month or dapsone 50 mg/day. The selection of prophylaxis regimen was individualized based on history of drug allergies, cost, and access to respiratory equipment. Patients were followed for evidence of PCP and toxicity. Crossover to the other prophylaxis regimens were allowed for toxicity. TABULAR DATA, SEE ABSTRACT VOLUME. Adverse events were observed in 5/98 for TMP/SMX in 2/7 for dapsone and in none with pentamidine although 7 discontinue the drug for equipment problems. In patients with AIDS who receive zidovudine TMP/SMX is more effective and safe, dapsone has the lowest cost but requires further evaluation while pentamidine was found with many logistic problems in Greece.

*AIDS-Related Opportunistic Infections/PREVENTION & CONTROL *Dapsone/THERAPEUTIC USE *Pentamidine/THERAPEUTIC USE *Pneumonia, Pneumocystis carinii/PREVENTION & CONTROL *Trimethoprim-Sulfamethoxazole Combination/THERAPEUTIC USE

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