Int Conf AIDS. 1993 Jun 6-11;9(1):367 (abstract no. PO-B09-1390). Unique
The emergence of fluconazole-resistant Candida species has recently been
recognized as a problem in AIDS patients during fluconazole prophylaxis.
We have isolated from the oral cavities of 22 AIDS patients, with oral
thrust, 36 Candida strains fluconazole-resistant. They were tested for
susceptibility by means of a photometer-read broth microdilution method
with RPMI 1640 medium according to NCCLS guidelines. Clinical resistance
was considered in case of failure after treatment with fluconazole 200
mg/d x 10 d. 95% of patients had received prolonged prophylactic
treatment with fluconazole. Yeast isolates were identified as C.
albicans (30), C. krusei (3), C. glabrata 2) and C. tropicalis (1). C.
albicans is the predominant yeast in oral thrust fluconazole-resistant
of AIDS patients. Other yeast species can emerge as human pathogens in
patients treated chronically with fluconazole.
*AIDS-Related Opportunistic Infections/MICROBIOLOGY *Candida/ISOLATION
& PURIF *Candida albicans/ISOLATION & PURIF *Candidiasis,
Oral/MICROBIOLOGY *Drug Resistance, Microbial *Fluconazole/TOXICITY