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Influence of HIV infection on tuberculosis.
Guerin B; Joly V; Vallee E; Bouvet E; Bouchaud O; Longuet P; Hopital
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):323 (abstract no. PO-B07-1126). Unique

OBJECTIVES: To assess manifestations of tuberculosis in HIV-infected (HIV+) patients (Pts) compared to non HIV-infected HIV-) Pts. METHODS: 60 HIV+ Pts and 63 HIV- Pts with bacteriologically proven tuberculosis were selected for a retrospective period of 12 months. RESULTS: HIV+ Pts differed from HIV- Pts by the frequency of multi-visceral localizations Multi Tub), tuberculous lymph nodes, typical chest X-ray, tuberculin skin test induration > 5 mm (PPD+), and tolerance of treatment. TABULAR DATA, SEE ABSTRACT VOLUME. In 28 Pts (23%), the strain was resistant to at least one of the major antituberculous drugs, but the percentage of resistant strains was similar in HIV+ and HIV- Pts (26.6 vs 19%). The frequency of smear-positive Pts was similar in HIV+ and HIV- Pts (40 vs 43%). Within the group of HIV+ Pts with pulmonary tuberculosis, Pts with CD4 count < 150 differed from Pts with CD4 count > 150 by the lower percentages of PPD+ (28% vs 92%, p < 0.05) and typical chest X-ray (33% vs 66%, p < 0.05). Rashes occurred in 8 HIV+ Pts and 1 HIV- Pt. Pyrazinamide was the drug the most frequently involved in the occurrence of toxicity (24% of all Pts), and was more often toxic in HIV+ than in HIV- Pts (36% vs 9%, p < 0.05). CONCLUSION: In this study, HIV infection did not influence the risk of resistant strain or smear-positive tuberculosis, but favored multi-visceral tuberculosis and lymph node localization, atypical radiologic presentation, and poor tolerance of therapy. The frequency of poorly specific symptoms increased with deep immunodeficiency.