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NLM AIDSLINE
Increase of HIV-2 and HIV-1 infection in tuberculosis (TB) cases in Guinea Bissau.
Sabbatani S; Ferro A; Gomes VF; Garcia Lacerda L; Tamburini M; Monaco M;
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):316 (abstract no. PO-B06-1087). Unique

OBJECTIVE: To evaluate if an increase of TB correlated to HIV-2 infection occurs, and if there is an appearance of HIV-1 infection among TB patients in a Country where the prevalent serotype is HIV-2. METHODS: From August '91 to July '92 we studied 630 TB patients, 366 males average age 42 y. (R 87.2) and 264 females average age 40 y (R 75-1) with evaluation of HIV-2 and HIV-1 (ELISA and Western blot). RESULTS: In the last 5 months of '91, 50 of the 260 pt. (19.23%) were HIV-2 positive, 2 (0.76%) were HIV-1 positive, and 1 showed also by W.B. double reactivity. In the first 7 months of '92, 81 (21.9%) of the 370 studied were HIV-2 positive, 9 (2.43%) were HIV-1 positive and 7 (1.89%) showed double reactivity by W.B. The overall HIV-2 and HIV-1 seroprevalence was 26%. CONCLUSIONS: The studies we made in 1990 showed in TB patients and HIV-2 seroprevalence of 17.73% while in 1989 it was of 14.8%. The epidemiological data which we possess show a substantial stability in Guinea Bissau of new TB cases registered in 1990 (1153) and 1991 (1105) (unpublished), while there is an increase in seroprevalence for HIV-2 and recently for HIV-1. Further longitudinal studies on this patient's population are needed to determine the specific role of HIV-2 and HIV-1 in TB spreading and evolution.

*AIDS-Related Opportunistic Infections/EPIDEMIOLOGY *HIV Infections/EPIDEMIOLOGY *HIV-1 *HIV-2 *Tuberculosis, Pulmonary/EPIDEMIOLOGY

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