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Co-infection with herpesviruses in young children of HIV infected women.
Sever J; Rakusan T; Frenkel N; Wyatt L; O'Donnell R; Price V; Children's
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):292 (abstract no. PO-B02-0939). Unique

To investigate the possible effects of co-infection with herpesviruses in infants and young children born to HIV infected mothers we studied patients who were 9 to 12 months of age and 15 to 24 months old. Three patient groups were included: 1) PCR and/or culture negative, asymptomatic (HIV-), 2) PCR and/or culture positive, asymptomatic (HIV+ asymptomatic), and 3) PCR and/or culture positive and symptomatic (HIV+, symptomatic). Antibody titers were determined for CMV using latex agglutination and for Ebstein-Barr Virus (EBV), Herpesviruses 6 and 7 (HHV-6, HHV-7) with fluorescence. CMV positivity varied significantly among the three patient groups (chi (2) = 8,373, 2df, p = 0.0152). Pairwise comparisons showed that significantly more of the HIV+, symptomatic patients (8/9) had CMV antibody than the HIV- patients (9/27). In addition, CMV antibody levels were significantly higher in the HIV+, symptomatic patients than in either of the other two groups (F = 5.52, p = .0073). HHV7 antibody titers were significantly different among the three groups of patients (p = .048), however, no pairwise comparisons were significant (p < .05). No differences were found for EBV or HHV-6 antibody frequencies or titers for these patient groups. Preliminary comparisons of antibody levels for the four viruses studied at 9 to 12 months of age and again at 15 to 24 months showed no evidence of change. CONCLUSION: These findings raise the possibility that infection with CMV may be a cofactor in symptomatic HIV in young children.

*Herpesviridae Infections/COMPLICATIONS *Herpesviridae Infections/TRANSMISSION *HIV Infections/COMPLICATIONS *HIV Infections/TRANSMISSION *Maternal-Fetal Exchange