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HIV-related fatigue.
Williams C; Lubeck DP; Department of Medicine, Stanford University,
November 30, 1993
Int Conf AIDS. 1993 Jun 6-11;9(1):282 (abstract no. PO-B01-0885). Unique

AIMS: Though there are limited data, fatigue is thought to be extremely common among persons with HIV infection, resulting in significant functional limitations. This study describes the frequency and extent of fatigue in at-risk (HIV-) and HIV-positive males followed in ATHOS. METHODS: We compared 394 HIV-, 326 asymptomatic (HIV+), 273 ARC, and 318 AIDS individuals. Self-reported fatigue in the past 7 days, the Energy and Mental Health indices from the Medical Outcomes Study, other disease symptoms, side effects, and HIV status were collected at the first questionnaire. An ANACOVA model (adjusted for mental health, side effects, and symptoms) was specified to estimate the Energy index score for each group. RESULTS: Fatigue was the most frequently reported symptom for AIDS patients (55.8%); 28.4%, 17.3%, and 5.1% of ARC, HIV+, and HIV-patients, respectively, reported fatigue (p < .01). Fatigue was also reported as a treatment side effect in 5.4% of AIDS patients, 6.2% of ARC patients, and 4.3% of HIV+ patients. Adjusting for mental health, total symptoms, reported fatigue symptom, or side effect, predicted scores on the Energy Index were 55.6 (SE = 1.1) for AIDS (100 is optimal), 58.4 (SE = 1.1) for ARC, and 62.8 (SE = 0.7) for HIV+ patients. ARC and AIDS patients had significantly worse fatigue (p < .001) than HIV+ individuals. DISCUSSION: The results are consistent with our expectations that AIDS and ARC patients report significant fatigue. HIV- individuals report levels of fatigue more similar to HIV+ individuals than the general population.