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The relationship between age and cognitive impairment in HIV-1 infection: findings from the Multicenter AIDS Cohort Study and a clinical cohort.
van Gorp WG; Miller EN; Marcotte TD; Dixon W; Paz D; Selnes O; Wesch J;
August 30, 1994
Neurology. 1994 May;44(5):929-35. Unique Identifier : AIDSLINE

Previous studies have identified age as a risk factor for many neurologic disorders, and a cerebral reserve factor has been postulated to explain these findings. This study examined whether age represents a risk factor for HIV-1-related neuropsychological dysfunction. Subjects for study 1 were primarily asymptomatic seropositive (n = 1,066) and seronegative (n = 1,004) nonelderly male community volunteers who completed neuropsychological and reaction time measures. Data analyses revealed a significant effect for age on reaction time and timed neuropsychological measures, but no interaction between age and serostatus. Study 2, employing a similar neuropsychological battery, consisted of 76 seropositive men (29 over age 55) recruited from community outpatient clinics and 47 seronegative controls. We found serostatus and age to have main effects on a number of measures, but a trend for an effect of age-serostatus interaction on only one measure.

Adult Aged *Aging AIDS Dementia Complex/PHYSIOPATHOLOGY Cognition Disorders/*ETIOLOGY/PHYSIOPATHOLOGY Cohort Studies Female Human HIV Infections/*COMPLICATIONS/PHYSIOPATHOLOGY/PSYCHOLOGY Male Middle Age Multicenter Studies Neuropsychological Tests Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE