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Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: a potential diagnostic pitfall with fine-needle aspiration cytology.
Wax TD; Layfield LJ; Zaleski S; Bhargara V; Cohen M; Lyerly HK; Fisher
August 30, 1994
Diagn Cytopathol. 1994;10(2):169-72; discussion 172-4. Unique Identifier

We report three cases of cytomegalovirus (CMV) sialadenitis which presented as parotid gland nodules in patients infected with the human immunodeficiency virus. While CMV is known to widely infect patients with the acquired immunodeficiency syndrome (AIDS), we are aware of only a single report of CMV sialadenitis in a patient with AIDS (Pialoux et al.: Rev Infect Dis 1991;13:338). Utilizing fine-needle aspiration (FNA) cytology as the initial investigative modality, two cases were correctly diagnosed preoperatively while the third case displayed atypical features and was interpreted erroneously as carcinoma leading to surgical intervention. Upon review of these cases of CMV sialadenitis, the characteristic intranuclear inclusions are best identified with Papanicolaou (Pap) staining. CMV sialadenitis should be considered in the differential diagnosis of painless salivary gland enlargement in patients with AIDS. We believe this lesion can be diagnosed preoperatively with FNA and the interpretation is aided by evaluating both Pap- and Giemsa-stained material.

Adult AIDS-Related Opportunistic Infections/*PATHOLOGY Biopsy, Needle Case Report Cytomegalovirus Infections/*PATHOLOGY Diagnostic Errors Human Immunohistochemistry Male Parotid Neoplasms/PATHOLOGY Sialadenitis/MICROBIOLOGY/*PATHOLOGY JOURNAL ARTICLE