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Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohorts.
Lifson AR; Hilton JF; Westenhouse JL; Canchola AJ; Samuel MC; Katz MH;
September 30, 1994
AIDS. 1994 Jan;8(1):73-9. Unique Identifier : AIDSLINE MED/94280707

OBJECTIVES: We evaluated time from HIV seroconversion to diagnosis of two common oral lesions associated with HIV infection and disease progression. DESIGN: Oral examinations were performed on homosexual and bisexual men enrolled in prospective cohorts. SETTING: Homosexual and bisexual men were followed in three epidemiologic cohort studies in San Francisco, California, USA. PARTICIPANTS: Data were evaluated from 80 men with well-defined dates of HIV seroconversion from 1984 through 1991. MAIN OUTCOME MEASURES: We determined the cumulative incidence of oral candidiasis and hairy leukoplakia after HIV seroconversion. RESULTS: Four per cent of men developed oral candidiasis within 1 year after HIV seroconversion, 8% within 2, 15% within 3, 18% within 4, and 26% within 5 years. Nine per cent developed hairy leukoplakia within 1 year, 16% within 2, 25% within 3, 35% within 4, and 42% within 5 years. The median CD4+ count was 391 x 10(6)/l when oral candidiasis was first reported and 468 x 10(6)/l when hairy leukoplakia was first reported. CONCLUSIONS: Oral candidiasis or hairy leukoplakia appeared in a significant proportion of HIV-infected homosexual and bisexual men. These lesions occurred relatively soon after HIV seroconversion, typically before AIDS. Evaluation of HIV-infected individuals for these lesions has many potential clinical and research benefits, including the possible use of oral lesions as primary end-points in clinical trials.

Adolescence Adult Aged AIDS-Related Opportunistic Infections/*DIAGNOSIS Bisexuality Candidiasis, Oral/*DIAGNOSIS Cohort Studies Homosexuality Human HIV Seropositivity/COMPLICATIONS/*PHYSIOPATHOLOGY Leukoplakia, Hairy/*DIAGNOSIS Male Middle Age Prospective Studies Support, U.S. Gov't, P.H.S. Time Factors JOURNAL ARTICLE