AIDS. 1994 Jan;8(1):73-9. Unique Identifier : AIDSLINE MED/94280707
OBJECTIVES: We evaluated time from HIV seroconversion to diagnosis of
two common oral lesions associated with HIV infection and disease
progression. DESIGN: Oral examinations were performed on homosexual and
bisexual men enrolled in prospective cohorts. SETTING: Homosexual and
bisexual men were followed in three epidemiologic cohort studies in San
Francisco, California, USA. PARTICIPANTS: Data were evaluated from 80
men with well-defined dates of HIV seroconversion from 1984 through
1991. MAIN OUTCOME MEASURES: We determined the cumulative incidence of
oral candidiasis and hairy leukoplakia after HIV seroconversion.
RESULTS: Four per cent of men developed oral candidiasis within 1 year
after HIV seroconversion, 8% within 2, 15% within 3, 18% within 4, and
26% within 5 years. Nine per cent developed hairy leukoplakia within 1
year, 16% within 2, 25% within 3, 35% within 4, and 42% within 5 years.
The median CD4+ count was 391 x 10(6)/l when oral candidiasis was first
reported and 468 x 10(6)/l when hairy leukoplakia was first reported.
CONCLUSIONS: Oral candidiasis or hairy leukoplakia appeared in a
significant proportion of HIV-infected homosexual and bisexual men.
These lesions occurred relatively soon after HIV seroconversion,
typically before AIDS. Evaluation of HIV-infected individuals for these
lesions has many potential clinical and research benefits, including the
possible use of oral lesions as primary end-points in clinical trials.
Adolescence Adult Aged AIDS-Related Opportunistic
Infections/*DIAGNOSIS Bisexuality Candidiasis, Oral/*DIAGNOSIS Cohort
Studies Homosexuality Human HIV
Hairy/*DIAGNOSIS Male Middle Age Prospective Studies Support, U.S.
Gov't, P.H.S. Time Factors JOURNAL ARTICLE