translation agency

NLM AIDSLINE
Synthesis of a new hydroxyethylene dipeptide isostere Phe psi [CH2CH (OH)]Phe as HIV-1 protease inhibitor.
Chen HG; Sawyer TK; Wuts PG; Upjohn Laboratories, Upjohn Company,
September 30, 1994
Chung Kuo Yao Li Hsueh Pao. 1994 Jan;15(1):33-5. Unique Identifier :

A new type of pseudopeptide isostere exampled by Phe psi[CH2CH(OH)]Phe was synthesized from phenylalanine. The HIV protease inhibitory activity (IC50) of Noa-His-Phe psi[CH2CH(OH)]Phe-Ile-Amp was 0.8 pmol.L-1.

Dipeptides/CHEMISTRY/*CHEMICAL SYNTHESIS HIV Protease Inhibitors/CHEMISTRY/*CHEMICAL SYNTHESIS Structure-Activity Relationship JOURNAL ARTICLE

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