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HIV-2 EHO isolate has a divergent envelope gene and induces single cell killing by apoptosis.
Rey-Cuille MA; Galabru J; Laurent-Crawford A; Krust B; Montagnier L;
September 30, 1994
Virology. 1994 Jul;202(1):471-6. Unique Identifier : AIDSLINE

The human immunodeficiency virus type 2 (HIV-2)-related isolate, referred to as HIV-2 EHO, has been isolated from an Ivory Coast patient with acquired immunodeficiency syndrome (AIDS). Infection of CD4 expressing cells with this highly infectious virus mediates a cytopathic effect characterized by single-cell killing as a consequence of apoptosis. Nucleotide sequence analysis of the HIV-2 EHO genome revealed a significant degree of divergence of its envelope gene from that of other known HIV-2 strains. This divergence for the deduced amino acid sequence corresponding to the extracellular envelope glycoprotein was 26 to 30%. These unique genetic and biological properties suggest that the HIV-2 EHO isolate is a distinct prototype in the HIV-2 family.

Acquired Immunodeficiency Syndrome/MICROBIOLOGY Amino Acid Sequence *Apoptosis Cells, Cultured *Genes, env Giant Cells/MICROBIOLOGY Human HIV Envelope Protein gp120/GENETICS HIV-2/CLASSIFICATION/*GENETICS/PATHOGENICITY Molecular Sequence Data Sequence Homology, Amino Acid Support, Non-U.S. Gov't *Variation (Genetics) JOURNAL ARTICLE