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NLM AIDSLINE
Incidence and prevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and cytomegalovirus among health care personnel at risk for blood exposure: final report from a longitudinal study [see comments]
Gerberding JL; Department of Medicine (Infectious Diseases), University
March 30, 1995
J Infect Dis. 1994 Dec;170(6):1410-7. Unique Identifier : AIDSLINE

In a 10-year dynamic cohort study, 976 health care providers were followed a mean of 1.9 years to evaluate the risk of human immunodeficiency virus (HIV) transmission, delayed seroconversion, and seronegative latent infection following occupational exposures. The seroprevalence and incidence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and cytomegalovirus (CMV) infection were also measured, with annual serologic testing for viruses and postexposure HIV tests. One of 327 percutaneous exposures (0.31%; confidence interval, 0.008%-1.69%) and 0 of 398 mucocutaneous exposures to HIV-infected blood transmitted HIV. Neither delayed seroconversions nor seronegative latent infections were detected. The baseline seroprevalences of HBV, HIV, HCV, and CMV infection were 21.7%, 0, 1.4%, and 43.4%, respectively. Corresponding incidence density rates were 3.05, 0.055, 0.08, and 2.48 (per 100 person-years). Despite infection control precautions and availability of hepatitis B vaccine, these health care providers remain at risk for acquiring bloodborne viral infections.

Blood/VIROLOGY *Blood-Borne Pathogens Cohort Studies Comparative Study Cytomegalovirus Infections/*EPIDEMIOLOGY Female HIV Infections/*EPIDEMIOLOGY/TRANSMISSION *Health Personnel Hepatitis B/*EPIDEMIOLOGY Hepatitis C/*EPIDEMIOLOGY Human Incidence Longitudinal Studies Male *Occupational Exposure Prevalence San Francisco/EPIDEMIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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