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Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1.
Schutten M; Andeweg AC; Bosch ML; Osterhaus AD; Erasmus University
April 30, 1995
Scand J Immunol. 1995 Jan;41(1):18-22. Unique Identifier : AIDSLINE

Enhancement of virus infectivity after sCD4 treatment has been documented for SIVagm and HIV-2. It has been suggested that a similar phenomenon may play a role in HIV-1 infection. In the present study we have analysed biological activities of virus neutralizing polyclonal and monoclonal human antibodies and of sCD4, towards HIV-1 chimeras with envelope proteins derived from one donor, which display different biological phenotypes. The antibodies, which recognize the V3 and/or the CD4 binding domains of the glycoproteins of these viruses and also sCD4 showed different levels of virus neutralizing activity toward the syncytium inducing HIV-1 strains. In contrast, they all dramatically enhanced the infectivity of an HIV-1 chimera with an envelope glycoprotein displaying the non-syncytium-inducing phenotype. Given the relatively conserved nature of non-syncytium-inducing HIV-1 surface glycoproteins early after infection, these data suggest a major role for antibody mediated enhancement of virus infectivity in the early pathogenesis of HIV-1 infection.

Antibodies, Monoclonal/IMMUNOLOGY Antibody Affinity Antigens, CD4/*METABOLISM Cell Fusion Gene Products, env/IMMUNOLOGY Human HIV Antibodies/*IMMUNOLOGY HIV-1/IMMUNOLOGY/*PATHOGENICITY In Vitro Neutralization Tests Support, Non-U.S. Gov't JOURNAL ARTICLE