Pediatr Res. 1994 Oct;36(4):456-60. Unique Identifier : AIDSLINE
EBV has been associated with several malignancies in humans. EBV can
also infect marmoset B lymphocytes, which, as opposed to human B cells,
are permissive for lytic Epstein-Barr viral replication. Mice with a
severe combined immunodeficiency phenotype (SCID mice) are extremely
susceptible to EBV-induced lymphomagenesis when inoculated with
EBV-infected lymphocytes. We inoculated SCID mice with human and
marmoset lymphoblastoid cells infected with the same EBV isolates. The
marmoset cells never gave rise to lymphomas, even after the
administration of acyclovir or an anti-natural killer cell antibody and
observation periods of up to 16 wk. In contrast, the human
lymphoblastoid cells nearly always gave rise to lymphomas within 8 wk.
Furthermore, human lymphoblastoid cells genetically engineered to permit
lytic EBV replication also readily formed tumors in the SCID mouse.
Thus, in this system, it is the cellular milieu that is crucial in
determining whether a given lymphoblastoid cell will give rise to a
tumor, not the EBV isolate harbored by the cell or whether the virus is
permitted to undergo lytic replication.
Animal Callithrix Cell Line *Cell Transformation, Neoplastic
Comparative Study *Herpesvirus 4, Human Human Lymphoma/*PATHOLOGY
Mice Mice, SCID Support, U.S. Gov't, P.H.S. Transplantation,
Heterologous Tumor Cells, Cultured JOURNAL ARTICLE