Infusionsther Transfusionsmed. 1994 Oct;21(5):333-6. Unique Identifier :
We studied the course of a primary HIV infection in a 54-year-old woman.
Probably the source of infection was sexual intercourse, since other
risks, such as i.v. drug use, acupuncture and transfusion were excluded.
On admission she presented with fever, a maculopapular rash, and
moderate enlargement of nuchal lymph nodes. At that time the anti-HIV
1,2 enzyme immunoassay was negative. However, the HIV-p24 Ag test, which
was performed in every HIV screening in our laboratory, was positive.
The suspicion of an acute HIV infection was supported by a positive
HIV-cDNA-PCR and confirmed by Western blot after seroconversion. As
additional finding, the blood smear showed abnormal white cell
differential count, indicating viral infection. Aminotransferases were
slightly increased, and antibodies to hepatitis B surface and core
antigens demonstrated former hepatitis B infection. It is concluded that
in this case the HIV-p24 Ag test proved its suitability for early
diagnosis of an acute HIV infection. In case of testing blood donors,
none of the compulsory serological screening methods would have detected
the HIV infection.
Acute Disease AIDS Serodiagnosis/*METHODS Blotting, Western Breast
Neoplasms/SURGERY Case Report Female Human HIV Core Protein
p24/*BLOOD HIV Infections/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION HIV
Seropositivity/DIAGNOSIS/IMMUNOLOGY Mastectomy Middle Age Polymerase
Chain Reaction Postoperative Complications/DIAGNOSIS/IMMUNOLOGY