Clin Infect Dis. 1994 Oct;19(4):789-91. Unique Identifier : AIDSLINE
Atypical mycobacteria, which are common opportunistic pathogens in
patients with AIDS, have not been previously implicated in the
pathogenesis of paranasal sinus infections; we describe two such
patients. Clinical and radiographic evidence of bilateral maxillary and
ethmoid sinusitis was observed for one patient; his infection proved
resistant to therapy with conventional antimicrobials and decongestants.
Endoscopic ethmoid sinus biopsy yielded a specimen containing acid-fast
bacilli (AFB) that were later identified as Mycobacterium kansasii.
Antimycobacterial therapy had not resulted in amelioration of the
sinusitis > 2 months later, at which time he died of cerebral
toxoplasmosis. The second patient presented with a tender right
frontotemporal soft-tissue mass; a computed tomogram disclosed that it
extended through the frontal bone to the frontal sinus. Inflamed tissue
debrided from the sinus contained AFB; cultures first yielded M.
kansasii and later Mycobacterium avium complex. Bacteremia due to both
organisms was also demonstrated. Infection progressed despite therapy.
Adult AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
*MICROBIOLOGY Case Report Human Male *Mycobacterium Infections,
Atypical/DIAGNOSIS/DRUG THERAPY Mycobacterium, Atypical/*ISOLATION &
PURIF Paranasal Sinus Diseases/DIAGNOSIS/DRUG THERAPY/*MICROBIOLOGY