Br J Haematol. 1994 Oct;88(2):397-9. Unique Identifier : AIDSLINE
In order to investigate a possible interaction between HIV and HCV
infections, we compared HCV RNA levels in 29 matched pairs of
haemophilic patients seropositive for HCV and serodiscordant for HIV.
Levels were assayed using the new Chiron Quantiplex bDNA assay and were
found to be significantly higher in HIV seropositive patients. There was
no association between HCV RNA and age, duration of HCV infection,
concentrate usage, markers of HIV progression, or use of zidovudine. Our
study supports the hypothesis that HIV infection facilitates HCV
replication and leads to more severe liver damage.
Adolescence Adult Aged Child Cross-Sectional Studies
Hemophilia/*COMPLICATIONS Hepatitis C/*COMPLICATIONS Hepatitis C
Viruses/*IMMUNOLOGY/PHYSIOLOGY Human HIV Seropositivity/*COMPLICATIONS
Middle Age RNA, Viral/BLOOD Support, Non-U.S. Gov't
Viremia/COMPLICATIONS Virus Replication JOURNAL ARTICLE