translation agency

NLM AIDSLINE
Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients.
Rady PL; Yen A; Rollefson JL; Orengo I; Bruce S; Hughes TK; Tyring SK;
August 30, 1995
Lancet. 1995 May 27;345(8961):1339-40. Unique Identifier : AIDSLINE

Herpesvirus-like DNA sequences (KSHV) have been reported to be associated with various forms of Kaposi's sarcoma (KS). To determine if KSHV was associated with other proliferative skin lesions from non-AIDS immunocompromised patients, 33 skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrhoeic keratosis) from 4 organ-transplant patients receiving immunosuppressive therapy were tested for KSHV by PCR. KSHV sequences were detected in 82% of these skin lesions. Our results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients.

*Base Sequence Carcinoma, Basal Cell/GENETICS/VIROLOGY Carcinoma, Squamous Cell/GENETICS/VIROLOGY Dermatitis, Seborrheic/GENETICS/VIROLOGY DNA, Viral/ANALYSIS/*GENETICS Gene Expression Regulation, Viral Globin/ANALYSIS/GENETICS Herpesviridae/*GENETICS Human Immunocompromised Host Keratosis/GENETICS/VIROLOGY *Organ Transplantation Polymerase Chain Reaction Sarcoma, Kaposi's/GENETICS/VIROLOGY Skin Diseases/GENETICS/*VIROLOGY Skin Neoplasms/GENETICS/*VIROLOGY Warts/GENETICS/VIROLOGY JOURNAL ARTICLE

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