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NLM AIDSLINE
[Adult T-cell leukemia associated with HTLV-1 in a HIV-2 seropositive African]
Mahe A; Gessain A; Huerre M; Valensi F; Keita S; Bobin P; Institut
September 30, 1995
Ann Dermatol Venereol. 1994;121(10):704-9. Unique Identifier : AIDSLINE

INTRODUCTION. The aim of this report is to describe an HIV-2 seropositive patient from Mali who had adult-T cell Leukaemia/Lymphoma associated with HTLV-I infection. CASE REPORT. The patient presented with erythroderma and foliate lymphocyte leukaemia. Skin biopsy showed an epidermotropic lymphoma. Tumoural cells expressed a mature T-cell phenotype CD4+/CD25+. High anti-HTLV-I titers and the evidence of monoclonal integration of HTLV-I provirus within circulating lymphoid cells led to the confirmation of HTLV-I as the causal agent in tumour cell transformation. HIV-2 serology was positive. DISCUSSION. Sub-Saharan Africa is a vast reservoir of HTLV-I virus with at least 5 million infected persons. Cases of adult-T cell Leukaemia/Lymphoma in Africans are exceptional. Lack of sufficient knowledge of the disease could partially explain this discrepancy. The main differential diagnosis in dermatology is primary T-cell lymphomas of the skin, particularly mycosis fungoides and Sezary syndrome.

Adult Africa South of the Sahara Case Report Dermatitis, Exfoliative/ETIOLOGY/PATHOLOGY English Abstract Human HIV Infections/*COMPLICATIONS HIV Seropositivity *HIV-1 *HIV-2 Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/ *COMPLICATIONS/PATHOLOGY Male Skin Neoplasms/*COMPLICATIONS/PATHOLOGY JOURNAL ARTICLE

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