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Co-occurrence of HIV-associated cognitive/motor complex and other AIDS-defining illnesses.
Miller EN; Visscher BR; Bing EG; McArthur JC; Cohen BA; Anderson R;
December 30, 1995
Natl Conf Hum Retroviruses Relat Infect (1st). 1993 Dec 12-16;:143.

Objectives: While much is known about HIV-1-Associated Cognitive/Motor Complex (HACC), it remains unclear if there are groups of other AIDS-defining illnesses that may co- occur with HACC. The identification of such disease clusters might help in understanding the pathogenesis of HACC. Methods: We evaluated 783 gay/bisexual men with diagnoses of Cognitive/Motor Complex and/or AIDS who were enrolled in the Multicenter AIDS Cohort Study. Co-occurrence of illness was assessed using multiple chi-square analyses with HACC crossed with each AIDS-defining illness. We evaluated the co-occurrence of HACC (n=77) with all major AIDS-defining illnesses that had frequencies of 10 or greater in this population. Subjects could have more than one diagnosis. Results and Conclusions: HACC was significantly more likely to be diagnosed in conjunction with CMV retinitis (2.7 times more likely, p less than .0001) or MAC (3.3 times more likely, p less than .0001) as compared with the 10% base rate of HACC in this population. The joint occurrence of these diagnoses may be related to late-stage illness, since the incidence of all three of these diagnoses increases over ten-fold as CD4 counts drop below 100. It is also possible that some diagnoses of HACC are cases of CMV encephalopathy that have been overlooked. Additional research is warranted to investigate the significance of the joint occurrence of these diagnoses.

Adult Brain/RADIOGRAPHY Comparative Study Female Human HIV Infections/*COMPLICATIONS Male Maxillary Sinusitis/COMPLICATIONS/*EPIDEMIOLOGY/RADIOGRAPHY Prevalence Retrospective Studies Tomography, X-Ray Computed ABSTRACT